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Alloc-Val-Ala-OH

CAT: 0013-GTR19253579-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19253579-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alloc-Val-Ala-OH (((Allyloxy) carbonyl) -L-valyl-L-alanine) serves as a building block in the synthesis of Tesirine, which is a clinical antibody-drug conjugate (ADC) featuring a pyrrolobenzodiazepine (PBD) dimer payload. The Val-Ala sequence is cleaved specifically by cathepsin B. The Alloc group is stable towards piperidine and TFA, yet can be easily removed under mild conditions via palladium-catalyzed allyl transfer.
CAS Number
330970-70-2
Smiles
[C@H] (C (N[C@H] (C (O) =O) C) =O) (NC (OCC=C) =O) C (C) C
Molecular Formula
C12H20N2O5
Molecular Weight
272.298
Storage Conditions
-20°C
Notes
For research use only.

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