Dendrotoxin-I

CAT: 0804-HY-P3055Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P3055Size:1 Each
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Description
Dendrotoxin-I (DTX-I) is a potent K+ channels blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2 and KV1.6, respectively. Dendrotoxin-I, a neurotoxin, has the potential for cancer research[1][2][3].
CAS Number
[107950-33-4]
Product Name Alternative
DTX-I
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dendrotoxin-i.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)CCC(N)=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NC4)=O)CO)=O)CC5=CNC6=CC=CC=C56)=O)[C@@H](C)O)=O)CC7=CC=CC=C7)=O)=O)CCC(O)=O)=O)CSSC[C@H](NC8=O)C(N[C@H](C(N[C@H](C(N[C@H]9[C@@H](C)O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)CCC(N)=O)=O)CCCCN)=O)CCCCN)=O)CCCCN)=O)CCC(N)=O)=O)CC(N)=O)=O)CC%10=CC=C(O)C=C%10)=O)CC%11=CC=C(O)C=C%11)=O)CC%12=CC=CC=C%12)=O)C)=O)CCC3)=O)[C@H](CC)C)=O)CCCCN)=O)CCC(N)=O)=O)CC%13=CC=C(O)C=C%13)=O)CSSC[C@H](NC4=O)C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]8CCC(O)=O)=O)CCC(O)=O)=O)[C@H](CC)C)=O)[C@@H](C)O)=O)CCCCN)=O)CC%14=CC=CC=C%14)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CO)=O)CC(N)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)=O)CCC2)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CC%15=CNC=N%15)=O)CC(C)C)=O)[C@H](CC)C)=O)CSSC[C@H](NC9=O)C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)=O)CC(C)C)=O)CCCCN)=O)CCCNC(N)=N)=O)CC(C)C)=O)CCC1
Molecular Formula
C312H491N99O83S6
Molecular Weight
7149.24
References & Citations
[1]Qiwen Liao, et al. Novel Kunitz-like Peptides Discovered in the Zoanthid Palythoa caribaeorum through Transcriptome Sequencing. J Proteome Res. 2018 Feb 2;17 (2) :891-902. |[2]Tess Wright, et al. Firing frequency and entrainment maintained in primary auditory neurons in the presence of combined BDNF and NT3. Sci Rep. 2016 Jun 23;6:28584.|[3]Hui Zhang, et al. Preparation, characterization, and pharmacodynamics of thermosensitive liposomes containing docetaxel. J Pharm Sci. 2014 Jul;103 (7) :2177-2183.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Voltage-gated potassium channel

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