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KAI-11101

CAT: 0013-GTR19250283-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19250283-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KAI-11101 is a potent, brain-penetrant dual leucine zipper kinase (DLK/MAP3K12) inhibitor with a Ki of 0.7 nM. It blocks paclitaxel-induced c-Jun phosphorylation (IC50=95 nM) and MAPK pathway activation, making it a valuable tool for studying neuroprotection in models of chemotherapy-induced peripheral neuropathy and other neurological disorders.
CAS Number
3099935-02-8
Field of Research
Signal Transduction
Smiles
CCN1C2=C (C=CN (C2=O) [C@@H]3CCC (C[C@@H]3OC) (F) F) C (=N1) C4=CC (=C (N=C4) N) OC (F) F
Molecular Formula
C21H23F4N5O3
Molecular Weight
469.433
Storage Conditions
-20°C
Notes
For research use only.

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