Products for Research Use Only

RD-23

CAT: 0013-GTR19250227-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19250227-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RD-23 is an orally bioavailable, selective PROTAC degrader of RET, notably degrading the RETG810C mutant with a DC50 of 11.7 nM. It suppresses downstream Shc signaling and induces apoptosis, making it a valuable tool for in vitro and in vivo research on RET-driven cancers such as medullary thyroid carcinoma.
CAS Number
3053537-06-4
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
N#CC=1C=NN2C=C (C=C (C=3C=NC (=CC3) N4CC5N (CC6=CN=C (OC) C=C6) C (C4) C5) C12) N7CCC (N8CCN (CC8) CCCC#CC9=CC=CC=%10C (=O) N (CC9%10) C%11C (=O) NC (=O) CC%11) CC7
Molecular Formula
C52H56N12O4
Molecular Weight
913.079
Storage Conditions
-20°C
Notes
For research use only.