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PT-129

CAT: 0013-GTR19249065-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19249065-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PT-129 is a PROTAC degrader targeting the G3BP1/2 NTF2 domain to disrupt stress granule assembly and disassemble existing granules. This action inhibits ATF4-mediated signaling between fibroblasts and cancer cells, providing a tool for studying cancer cell stress resilience and tumor-stroma communication in vitro and in vivo.
Field of Research
Cell Biology, Molecular Biology, Pharmacology & Drug Discovery
Smiles
O=C (N (C1C (NC (CC1) =O) =O) C2=O) C3=C2C=CC=C3NCCOCCOCCOCCC (NC4=CC=C (NC ([C@H] (CC5=CC=CC=C5) NS (=O) (CC (N6C (C=CC=C7) =C7C=N6) =O) =O) =O) C=C4) =O
Molecular Formula
C46H48N8O12S
Molecular Weight
936.98
Storage Conditions
-20°C
Notes
For research use only.

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