Methyl palmitate

CAT: 0804-HY-N1482-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
CAT#:0804-HY-N1482-01Size:10 mM - 1 mL
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Description
Methyl palmitate is a naturally occurring fatty acid ester. Methyl palmitate is a potent inhibitor of ΙκB phosphorylation. Methyl palmitate modulates macrophage activity and down-regulates pro-inflammatory mediators such as TNF-α and nitric oxide (NO) . Methyl palmitate possesses anti-inflammatory and antifibrotic effects. Methyl palmitate can inhibit LPS (HY-D1056) -induced Kupffer cells and rat peritoneal macrophages. Methyl palmitate is able to inhibit the phagocytic function of RAW cells. Methyl palmitate is antagonistic to muscarinic receptors. Methyl palmitate exerts cardioprotective effects against ischemia/reperfusion injury in vivo. Methyl palmitate is highly toxic against adult T. cinnabarinus[1][2][3][4][5].
CAS Number
[112-39-0]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Interleukin Related; Parasite; TNF Receptor
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/methyl-palmitate.html
Purity
99.34
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 50 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCCCCCC(OC)=O
Molecular Formula
C17H34O2
Molecular Weight
270.45
Precautions
H302, H315, H319, H335
References & Citations
[1]El-Demerdash E, et al, Anti-inflammatory and antifibrotic effects of methyl palmitate. Toxicol Appl Pharmacol. 2011 Aug 1;254 (3) :238-44.|[2]N. R. Di Luzio, et al. Depression of phagocytic activity and immune response by methyl palmitate. Am J Physiol. 1964 May;206:939-43.|[3]Y. N. Wang, et al. Methyl Palmitate, an Acaricidal Compound Occurring in Green Walnut Husks. Journal of Economic Entomology, Volume 102, Issue 1, 1 February 2009, Pages 196–202.|[4]Saeed, N. M., et al., (2012) . Anti-inflammatory activity of methyl palmitate and ethyl palmitate in different experimental rat models. Toxicology and applied pharmacology, 264 (1), 84–93.|[5]Shen, Y. J., et al., (2021) . Methyl palmitate protects heart against ischemia/reperfusion-induced injury through G-protein coupled receptor 40-mediated activation of the PI3K/AKT pathway. European journal of pharmacology, 905, 174183.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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