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AMG-1694

CAT: 0013-GTR19244338-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19244338-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals.
CAS Number
1361217-07-3
Purity
>98% (HPLC)
Smiles
C ([C@@H]1N (CCN (S (=O) (=O) C2=CC=CS2) C1) C3=CC=C ([C@@] (C (F) (F) F) (C) O) C=C3) N4[C@@H] (C) COCC4
Molecular Formula
C23H30F3N3O4S2
Molecular Weight
533.63
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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