PROTAC MDM2 Degrader-1

PROTAC MDM2 Degrader-1

• CAS Number: 2249944-98-5
• UNSPSC Description: PROTAC MDM2 Degrader-1 (Compound 15a) is a MDM2 PROTAC degrader. The structures of both Linker ends of PROTAC MDM2 Degrader-1 are MDM2 ligands. PROTAC MDM2 Degrader-1 can not only block the binding of p53-MDM2, but also degrade the target MDM2 protein by utilizing the function of the E3 ligase of MDM2 itself, thus exerting an anti-tumor effect. (Pink: MDM2 ligand 2 (HY-128836); Black: Linker (HY-128844); Blue: E3 ligase Ligand 15 (HY-128836))[1]
• Target Antigen: MDM-2/p53; PROTACs
• Type: Reference compound
• Related Pathways: Apoptosis;PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-mdm2-degrader-1.html
• Purity: 98.11
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(N1CC(N(CC1)CC(NCCCOCCOCCOCCCNC(CN2C(CN(CC2)C(N3[C@@H](C4=CC=C(C=C4)Cl)[C@@H](C5=CC=C(C=C5)Cl)N=C3C6=C(C=C(C=C6)OC)OC(C)C)=O)=O)=O)=O)=O)N7[C@@H](C8=CC=C(C=C8)Cl)[C@@H](C9=CC=C(C=C9)Cl)N=C7C%10=C(C=C(C=C%10)OC)OC(C)C
• Molecular Weight: 1463.33
• References & Citations: [1]Method of inducing of self-degradation of MDM2 using E3 ubiquitin ligase dimer amide small molecule PROTACs. CN108610333A.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported