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GSK215

CAT: 0013-GTR19243755-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19243755-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader with a pDC50 of 8.4. GSK215 is designed by a binder for the VHL E3 ligase and the FAK inhibitor VS-4718. GSK215 induces rapid and prolonged FAK degradation, giving a long-lasting effect on FAK levels and a marked pharmacokinetic/pharmacodynamics (PK/PD) disconnect.
CAS Number
2743427-26-9
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 250 mg/mL (253.77 mM; Ultrasonic)
Smiles
CNC (=O) c1ccccc1Nc1cc (Nc2ccc (cc2OC) N2CCN (CC (=O) N[C@H] (C (=O) N3C[C@H] (O) C[C@H]3C (=O) N[C@@H] (C) c3ccc (cc3) -c3scnc3C) C (C) (C) C) CC2) ncc1C (F) (F) F
Molecular Formula
C50H59F3N10O6S
Molecular Weight
985.13
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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