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MS-8709

CAT: 0013-GTR19242088-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19242088-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MS-8709 is a potent and selective PROTAC degrader of G9a/GLP (EHMT2/EHMT1) with DC50 values of 274 nM and 260 nM, respectively. It induces target degradation via the UPS and demonstrates superior anti-proliferative activity in prostate cancer, leukemia, and lung cancer cell models compared to inhibitor UNC0642, supported by favorable murine PK for in vivo studies.
CAS Number
3060730-06-2
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Purity
99.98% (May vary between batches)
Smiles
N (C=1C2=C (N=C (N1) N3CCC (F) (F) CC3) C=C (OCCCN4CCCC4) C (OC) =C2) C5CCN (CCCC (NCCCCCCCCCCCC (N[C@H] (C (=O) N6[C@H] (C (NCC7=CC=C (C=C7) C8=C (C) N=CS8) =O) C[C@@H] (O) C6) [C@@] (C) (C) C) =O) =O) CC5
Molecular Formula
C64H95F2N11O7S
Molecular Weight
1200.57
Storage Conditions
-20°C
Notes
For research use only.

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