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AUT2

CAT: 0013-GTR19242646-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19242646-01Size:10 mg
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Description
AUT2 is a Kv3.1 potassium channel modulator that shifts channel activation to more negative potentials, reducing high-threshold K+ currents. This mechanism shows promise for treating sensory hyperreactivity in Fragile X Syndrome and hearing impairments, as evidenced by its ability to restore ABR wave IV in relevant research models.
CAS Number
1311137-58-2
Smiles
O=C1N (C (=O) N[C@@H]1CC) C=2C=CC (OC3=CC (C (C) C) =C (C#N) C=C3) =NC2
Molecular Formula
C20H20N4O3
Molecular Weight
364.4
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(R)-4-((5-(4-Ethyl-2,5-dioxoimidazolidin-1-yl)pyridin-2-yl)oxy)-2-isopropylbenzonitrile
CAS Number1311137-58-2
PubChem CID53241403
IUPAC Name4-[[5-[(4R)-4-ethyl-2,5-dioxoimidazolidin-1-yl]-2-pyridinyl]oxy]-2-propan-2-ylbenzonitrile
Molecular FormulaC20H20N4O3
Molecular Weight364.4
XLogP3.3
Topological Polar Surface Area95.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity614
SMILES
CC[C@@H]1C(=O)N(C(=O)N1)C2=CN=C(C=C2)OC3=CC(=C(C=C3)C#N)C(C)C
InChI
InChI=1S/C20H20N4O3/c1-4-17-19(25)24(20(26)23-17)14-6-8-18(22-11-14)27-15-7-5-13(10-21)16(9-15)12(2)3/h5-9,11-12,17H,4H2,1-3H3,(H,23,26)/t17-/m1/s1
InChIKey
XIOQUVPRNWUTBF-QGZVFWFLSA-N
Chemical Structure
2D Structure
2D structure of (R)-4-((5-(4-Ethyl-2,5-dioxoimidazolidin-1-yl)pyridin-2-yl)oxy)-2-isopropylbenzonitrile
CAS: 1311137-58-2
CID: 53241403
Formula: C20H20N4O3
MW: 364.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight364.4
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass364.15354051
Monoisotopic Mass364.15354051
Topological Polar Surface Area95.3 Ų
Heavy Atom Count27
Formal Charge0
Complexity614
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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