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FerroLOXIN-1

CAT: 0013-GTR19241204-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19241204-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FerroLOXIN-1 is a selective 15LOX-2 inhibitor that potently blocks the synthesis of pro-ferroptotic HOO-ETE-PE, thereby preventing RSL3-induced ferroptosis. Its mechanism involves specific interaction with key residues like Y154. This tool compound is valuable for investigating ferroptosis pathways in both cellular and animal models of related diseases.
CAS Number
2773428-48-9
Field of Research
Cell Biology, Metabolism Research
Smiles
FC1=CC=CC (=C1) N2C=C (N=C2NCC3=CC=C (C (F) =C3) C (F) (F) F) C=4C=CC=CC4
Molecular Formula
C23H16F5N3
Molecular Weight
429.39
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

FerroLOXIN-1
CAS Number2773428-48-9
PubChem CID163368838
IUPAC Name1-(3-fluorophenyl)-N-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]-4-phenylimidazol-2-amine
Molecular FormulaC23H16F5N3
Molecular Weight429.4
XLogP6.2
Topological Polar Surface Area29.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity568
SMILES
C1=CC=C(C=C1)C2=CN(C(=N2)NCC3=CC(=C(C=C3)C(F)(F)F)F)C4=CC(=CC=C4)F
InChI
InChI=1S/C23H16F5N3/c24-17-7-4-8-18(12-17)31-14-21(16-5-2-1-3-6-16)30-22(31)29-13-15-9-10-19(20(25)11-15)23(26,27)28/h1-12,14H,13H2,(H,29,30)
InChIKey
TZTVXYFOBQIIBL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of FerroLOXIN-1
CAS: 2773428-48-9
CID: 163368838
Formula: C23H16F5N3
MW: 429.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight429.4
XLogP36.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass429.12643833
Monoisotopic Mass429.12643833
Topological Polar Surface Area29.9 Ų
Heavy Atom Count31
Formal Charge0
Complexity568
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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