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TM6008

CAT: 0804-HY-112678-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112678-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TM6008 is a potent and orally active prolyl hydroxylase (PHD) inhibitor. TM6008 chelats transition metal (copper) and inhibits the autoxidation of ascorbic acid with an IC50 value is 0.57 μM. TM6008 exerts organ protection against ischemia in vivo and can be used for cerebrovascular disease research[1].
CAS Number
945008-17-3
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tm6008.html
Purity
99.51
Solubility
DMSO : 5.56 mg/mL (ultrasonic; adjust pH to 3 with 1 M HCl)
Smiles
O=C1N(C)C(C(C(C2=CC(C3=NC=CC=C3)=NC4=CC=CC=C24)=O)=C(N)N1C)=O
Molecular Formula
C21H17N5O3
Molecular Weight
387.39
Precautions
H315, H319, H335
References & Citations
[1]Masaomi Nangaku, et al. A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia. Arterioscler Thromb Vasc Biol. 2007 Dec;27 (12) :2548-54.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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