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TM6089

CAT: 0804-HY-118543-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118543-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TM6089 is a unique Prolyl Hydroxylase (PHD) inhibitor which stimulates HIF activity without iron chelation and induces angiogenesis and exerts organ protection against ischemia. Local administration of TM6089 enhances angiogenesis, and oral administration stimulates HIF activity in transgenic rats expressing a hypoxia-responsive reporter vector[1].
CAS Number
863421-32-3
Product Name Alternative
CS-505 (free base)
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tm6089.html
Purity
99.37
Solubility
DMSO : 41.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N(C(C(C(CSC2=NC=CC=C2)=O)=C(N1C)N)=O)C
Molecular Formula
C13H14N4O3S
Molecular Weight
306.34
References & Citations
[1]Nangaku M, et al. A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia. Arterioscler Thromb Vasc Biol. 2007 Dec;27 (12) :2548-54.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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