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PROTAC SMARCA2/4-degrader-30

CAT: 0013-GTR19239340-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19239340-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC SMARCA2/4-degrader-30 (I-291) is a potent, cell-permeable degrader of the SWI/SNF catalytic subunits SMARCA2 and SMARCA4, demonstrating DC50 values below 100 nM in cellular models like A549 and MV-411. This tool compound enables the study of chromatin remodeling complex function in cancer research and target validation, both in vitro and in vivo.
CAS Number
2568276-44-6
Field of Research
Epigenetics & Chromatin, Neuroscience, Pharmacology & Drug Discovery
Smiles
NC1=C (N2CC3N (C (C2) CC3) C=4N=CC (=CN4) C5CCN (CC5) [C@@H]6CC[C@H] (CC6) C=7C=C8C (=CC7) N (C (=O) N8C) C9C (=O) NC (=O) CC9) C=C (N=N1) C%10=C (O) C=CC=C%10
Molecular Formula
C44H51N11O4
Molecular Weight
797.95
Storage Conditions
-20°C
Notes
For research use only.

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