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SMIP004

CAT: 0804-HY-15694-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15694-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells[1][2].
CAS Number
143360-00-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smip004.html
Purity
99.79
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC1=C(NC(C)=O)C=CC(CCCC)=C1
Molecular Formula
C13H19NO
Molecular Weight
205.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Li C, et al. SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination. J Exp Clin Cancer Res. 2019 Feb 13;38 (1) :76.|[2]Rico-Bautista E, Zhu W, Kitada S, Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via UPR Signaling. Oncotarget. 2013 Jul 14.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
GTR19174158-01SMIP004
A15240-25SMIP004 25mg
A15240-10SMIP004 10mg
A15240-5SMIP004 5mg
A15240-1SMIP004 1mg
A15240-100SMIP004 100mg
A15240-50SMIP004 50mg
A15240-2SMIP004 2mg
A15240-10mM-DSMIP004 10mM * 1mL in DMSO
217795SKP2 E3 Ligase Inhibitor II, SMIP004 (CRL1SKP2 Inhibitor II, p21/Cip1/CKI/Waf1 Activator II, N- (4-Butyl-2-methylphenyl) acetamide, p27/Kip1 Activator II, S-phase Kinase-associated Protein 2 Inhibitor II, SCFSKP2 Inhibitor II, Small Molecule Inhibitor of p27 Depletion 004)

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