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MerTK/Axl-IN-1

CAT: 0013-GTR19238859-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19238859-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MerTK/Axl-IN-1 (A-910) is a potent, selective dual inhibitor of MerTK and Axl kinases, demonstrating low nanomolar IC50 values in both cellular (Ba/F3) and biochemical (HTRF) assays. It shows robust in vivo target engagement by inhibiting pMerTK, coupled with favorable pharmacokinetic properties including a long half-life and high oral bioavailability, making it a valuable tool for cancer and immunology research.
CAS Number
3036009-40-9
Field of Research
Signal Transduction
Smiles
C ([C@@H] (CO) O) N1CCN ([C@@H]2C=3C (=CC (=CC3) C4=CC=C (CO[C@@H]5[C@@H] (NC (=O) C=6C=C (C=NC6N) C7=C (F) N=CC=C7) CCC5) C=C4) CCC2) CC1
Molecular Formula
C40H47FN6O4
Molecular Weight
694.84
Storage Conditions
-20°C
Notes
For research use only.

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