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PROTAC SMARCA2/4-degrader-15

CAT: 0013-GTR19237772-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19237772-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC SMARCA2/4-degrader-15 (Compound I-335) is a potent, cell-permeable degrader of the SWI/SNF catalytic subunits SMARCA2 and SMARCA4, demonstrating DC50 values below 100 nM in A549 and MV411 cell lines. This tool compound is valuable for in vitro cancer research, particularly in studying oncogenic roles and synthetic lethal vulnerabilities in SMARCA4-deficient cancers.
CAS Number
2568276-81-1
Field of Research
Neuroscience
Smiles
NC1=C (N2CC3N (C (C2) CC3) C=4N=CC (=CN4) C5=CC=C (CC (N[C@H] (C (=O) N6[C@H] (C (NCC7=CC=C (C=C7) C8=C (C) N=CS8) =O) C[C@@H] (O) C6) C (C) (C) C) =O) C=C5) C=C (N=N1) C9=C (O) C=CC=C9
Molecular Formula
C50H55N11O5S
Molecular Weight
922.11
Storage Conditions
-20°C
Notes
For research use only.

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