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SR 13668

CAT: 0013-GTR19236275-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19236275-02Size:50 mg
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Description
SR13668 is an orally active indole-3-methanol analog designed to overcome the metabolic limitations of its parent compound. It potently inhibits growth factor-stimulated Akt activation, demonstrating robust in vivo anti-tumor efficacy and a favorable safety profile in preclinical cancer models.
CAS Number
637774-61-9
Field of Research
Signal Transduction
Smiles
O=C (OCC) C1=CC=C2NC=3C (OC) =C4NC=5C=CC (=CC5C4=CC3C2=C1) C (=O) OCC
Molecular Formula
C25H22N2O5
Molecular Weight
430.45
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

SR 13668

Akt Inhibitor SR13668 is an orally bioavailable indole-3-carbinol (I3C) analogue inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic and antiangiogenic activities. Akt inhibitor SR13668 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation, and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

CAS Number637774-61-9
PubChem CID9845566
IUPAC Namediethyl 6-methoxy-5,7-dihydroindolo[2,3-b]carbazole-2,10-dicarboxylate
Molecular FormulaC25H22N2O5
Molecular Weight430.5
XLogP5.3
Topological Polar Surface Area93.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count32
Formal Charge0
Complexity660
SMILES
CCOC(=O)C1=CC2=C(C=C1)NC3=C(C4=C(C=C23)C5=C(N4)C=CC(=C5)C(=O)OCC)OC
InChI
InChI=1S/C25H22N2O5/c1-4-31-24(28)13-6-8-19-15(10-13)17-12-18-16-11-14(25(29)32-5-2)7-9-20(16)27-22(18)23(30-3)21(17)26-19/h6-12,26-27H,4-5H2,1-3H3
InChIKey
BMTPVPNVQOYGAP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of SR 13668
CAS: 637774-61-9
CID: 9845566
Formula: C25H22N2O5
MW: 430.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight430.5
XLogP35.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass430.15287181
Monoisotopic Mass430.15287181
Topological Polar Surface Area93.4 Ų
Heavy Atom Count32
Formal Charge0
Complexity660
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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