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BTL-MK

CAT: 0013-GTR19236235-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19236235-02Size:10 mg
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Description
BTL-MK (Compound 19) is an orally bioavailable small molecule that binds the inhibitory FcγRIIB receptor, suppressing mast cell degranulation (IC50 = 6.7 μM) . It demonstrates improved metabolic stability and has shown efficacy in ameliorating allergic responses in an Ovalbumin-induced food allergy murine model, supporting its use in allergy and immunology research.
CAS Number
2758569-43-4
Smiles
C ([C@]1 (C (C) =O) C (=C (O) C (=O) O1) C2=CC=C (O) C=C2) C3=CC (CC=C (C) C) =C (O) C=C3
Molecular Formula
C24H24O6
Molecular Weight
408.44
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Btl-MK
CAS Number2758569-43-4
PubChem CID172420075
IUPAC Name(5R)-5-acetyl-3-hydroxy-5-[[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]methyl]-4-(4-hydroxyphenyl)furan-2-one
Molecular FormulaC24H24O6
Molecular Weight408.4
XLogP4.2
Topological Polar Surface Area104
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count30
Formal Charge0
Complexity726
SMILES
CC(=CCC1=C(C=CC(=C1)C[C@@]2(C(=C(C(=O)O2)O)C3=CC=C(C=C3)O)C(=O)C)O)C
InChI
InChI=1S/C24H24O6/c1-14(2)4-6-18-12-16(5-11-20(18)27)13-24(15(3)25)21(22(28)23(29)30-24)17-7-9-19(26)10-8-17/h4-5,7-12,26-28H,6,13H2,1-3H3/t24-/m0/s1
InChIKey
PCMOKDHSCASDSX-DEOSSOPVSA-N
Chemical Structure
2D Structure
2D structure of Btl-MK
CAS: 2758569-43-4
CID: 172420075
Formula: C24H24O6
MW: 408.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight408.4
XLogP34.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass408.15728848
Monoisotopic Mass408.15728848
Topological Polar Surface Area104 Ų
Heavy Atom Count30
Formal Charge0
Complexity726
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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