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CDDD11-8

CAT: 0013-GTR19235968-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19235968-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDDD11-8 is a potent, orally bioavailable small molecule inhibitor targeting CDK9 and FLT3-ITD with high selectivity (Ki = 8 nM and 13 nM, respectively) . It demonstrates strong anti-proliferative effects in vitro against FLT3-ITD-positive leukemia cell lines and has shown efficacy in relevant in vivo models, supporting its use in oncology research for acute myeloid leukemia.
CAS Number
2241659-94-7
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
CC=1C (C=2N3C (=NC2) C=CC (=C3) C4=CC=CC=C4) =NC (N[C@@H]5CC[C@@H] (N) CC5) =NC1
Molecular Formula
C24H26N6
Molecular Weight
398.50
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4-N-[5-methyl-4-(6-phenylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]cyclohexane-1,4-diamine
CAS Number2241659-94-7
PubChem CID135301300
IUPAC Name4-N-[5-methyl-4-(6-phenylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]cyclohexane-1,4-diamine
Molecular FormulaC24H26N6
Molecular Weight398.5
XLogP4.4
Topological Polar Surface Area81.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count30
Formal Charge0
Complexity544
SMILES
CC1=CN=C(N=C1C2=CN=C3N2C=C(C=C3)C4=CC=CC=C4)NC5CCC(CC5)N
InChI
InChI=1S/C24H26N6/c1-16-13-27-24(28-20-10-8-19(25)9-11-20)29-23(16)21-14-26-22-12-7-18(15-30(21)22)17-5-3-2-4-6-17/h2-7,12-15,19-20H,8-11,25H2,1H3,(H,27,28,29)
InChIKey
OVOYRPVIZNJKHS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-N-[5-methyl-4-(6-phenylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]cyclohexane-1,4-diamine
CAS: 2241659-94-7
CID: 135301300
Formula: C24H26N6
MW: 398.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight398.5
XLogP34.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass398.22189485
Monoisotopic Mass398.22189485
Topological Polar Surface Area81.1 Ų
Heavy Atom Count30
Formal Charge0
Complexity544
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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