Products for Research Use Only
RegisterLogin

EGFR/HER2-IN-10

CAT: 0013-GTR19235420-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19235420-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
EGFR/HER2-IN-10 (9F) is a potent and selective dual inhibitor of EGFR (IC50 = 2.3 nM) and HER2 (IC50 = 234 nM) . It demonstrates antiproliferative activity against prostate cancer cell lines in vitro, making it a useful chemical probe for oncology research targeting these receptor tyrosine kinases.
CAS Number
2931499-82-8
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
N (C=1C2=C (C=C (OC) C (OCCCCN3C (N (=O) =O) =NC=C3) =C2) N=CN1) C4=CC (Cl) =C (OC5=CC (C (F) (F) F) =CC=C5) C=C4
Molecular Formula
C29H24ClF3N6O5
Molecular Weight
628.99
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Egfr/her2-IN-10
CAS Number2931499-82-8
PubChem CID169494509
IUPAC NameN-[3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl]-7-methoxy-6-[4-(2-nitroimidazol-1-yl)butoxy]quinazolin-4-amine
Molecular FormulaC29H24ClF3N6O5
Molecular Weight629.0
XLogP7
Topological Polar Surface Area129
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count12
Rotatable Bond Count11
Heavy Atom Count44
Formal Charge0
Complexity922
SMILES
COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)OC4=CC=CC(=C4)C(F)(F)F)Cl)OCCCCN5C=CN=C5[N+](=O)[O-]
InChI
InChI=1S/C29H24ClF3N6O5/c1-42-25-16-23-21(15-26(25)43-12-3-2-10-38-11-9-34-28(38)39(40)41)27(36-17-35-23)37-19-7-8-24(22(30)14-19)44-20-6-4-5-18(13-20)29(31,32)33/h4-9,11,13-17H,2-3,10,12H2,1H3,(H,35,36,37)
InChIKey
OWTCMGIQRBBCSW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Egfr/her2-IN-10
CAS: 2931499-82-8
CID: 169494509
Formula: C29H24ClF3N6O5
MW: 629.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight629.0
XLogP37
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count12
Rotatable Bond Count11
Exact Mass628.1448801
Monoisotopic Mass628.1448801
Topological Polar Surface Area129 Ų
Heavy Atom Count44
Formal Charge0
Complexity922
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19234166-01EGFR/HER2-IN-13
GTR19185808-01EGFR/HER2-IN-2
GTR19185807-01EGFR/HER2-IN-3
GTR19263496-01EGFR/HER2-IN-19
GTR19262762-01EGFR/HER2-IN-15
GTR19237870-01EGFR/HER2-IN-16
GTR19235418-01EGFR/HER2-IN-12
GTR19233994-01EGFR/HER2-IN-14
GTR19212902-01EGFR/HER2-IN-9
GTR19186794-01EGFR/HER2-IN-6

Alternative Products

CatalogName
HY-157399EGFR/HER2-IN-10
HY-174841EGFR/HER2-IN-19
HY-174414EGFR/HER2-IN-18
HY-172623EGFR/HER2-IN-17
HY-161602EGFR/HER2-IN-13
T88221-01EGFR/HER2-IN-14
MBS5803977EGFR/HER2-IN-7
MBS5806914EGFR/HER2-IN-5
HY-160682EGFR/HER2-IN-12
HY-153111-01EGFR/HER2-IN-9

Popular Products