Products for Research Use Only

Pro-GA

CAT: 0013-GTR19241259-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19241259-03Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pro-GA is a cell-permeable small molecule inhibitor of γ-glutamylcyclotransferase (γ-GGCT) . It suppresses the proliferation of bladder cancer cell lines, such as T24 cells, with an IC50 of 57 μM, demonstrating its utility for in vitro oncology research into glutathione metabolism and cancer cell viability.
CAS Number
2222067-12-9
Field of Research
Cell Biology, Metabolism Research
Smiles
[C@H] (C (OCOC (C) =O) =O) (NC (CCCC (OC) =O) =O) C
Molecular Formula
C12H19NO7
Molecular Weight
289.28
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Pro-GA
CAS Number2222067-12-9
PubChem CID168446475
IUPAC Namemethyl 5-[[(2S)-1-(acetyloxymethoxy)-1-oxopropan-2-yl]amino]-5-oxopentanoate
Molecular FormulaC12H19NO7
Molecular Weight289.28
XLogP0
Topological Polar Surface Area108
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count11
Heavy Atom Count20
Formal Charge0
Complexity367
SMILES
C[C@@H](C(=O)OCOC(=O)C)NC(=O)CCCC(=O)OC
InChI
InChI=1S/C12H19NO7/c1-8(12(17)20-7-19-9(2)14)13-10(15)5-4-6-11(16)18-3/h8H,4-7H2,1-3H3,(H,13,15)/t8-/m0/s1
InChIKey
GYBSTWDRGMHMOZ-QMMMGPOBSA-N
Chemical Structure
2D Structure
2D structure of Pro-GA
CAS: 2222067-12-9
CID: 168446475
Formula: C12H19NO7
MW: 289.28
Interactive 3D Structure
Loading 3D structure...
Computed Properties
PropertyValue
Molecular Weight289.28
XLogP30
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count11
Exact Mass289.11615195
Monoisotopic Mass289.11615195
Topological Polar Surface Area108 Ų
Heavy Atom Count20
Formal Charge0
Complexity367
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes