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4A3-SCC-PH

CAT: 0013-GTR19240160-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19240160-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4A3-SCC-PH is a groundbreaking linker-degradable ionizable lipid (LDIL) that features a glutathione (GSH) -responsive cone-shaped molecular structure. This unique architecture enables superior endosomal escape and rapid mRNA release, making it highly effective for mRNA delivery. In vivo studies have highlighted its exceptional performance, showing a 176-fold increase in mRNA delivery efficiency to the liver compared to DLin-MC3-DMA, a widely used benchmark lipid. Both 4A3-SCC-PH and its structural analog, 4A3-SCC-10, also demonstrated significantly enhanced mRNA delivery efficacy compared to their non-disulfide-containing parent compounds and disulfide-containing controls with modified lipid tails.
Purity
>95%
Smiles
CN (CCCN (CCC (OCCSSCCOC (C (C) CSCC (CCC) CCCCC) =O) =O) CCC (OCCSSCCOC (C (C) CSCC (CCC) CCCCC) =O) =O) CCCN (CCC (OCCSSCCOC (C (C) CSCC (CCC) CCCCC) =O) =O) CCC (OCCSSCCOC (C (C) CSCC (CCC) CCCCC) =O) =O
Molecular Formula
C91H171N3O16S12
Molecular Weight
1948.094
Notes
For research use only.

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