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G-5758

CAT: 0013-GTR19234234-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19234234-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
G-5758 is a potent and orally bioavailable IRE1α inhibitor (IC50 = 38 nM against XBP1s) . It demonstrates pharmacodynamic activity comparable to genetic knockdown and has shown efficacy in multiple myeloma models like KMS-11, with good tolerability in rat studies at doses up to 500 mg/kg.
CAS Number
2413455-99-7
Field of Research
Cell Biology, Metabolism Research
Smiles
O (C1=C (C=CC=N1) C2=NC (N[C@H]3C[C@H] (F) CNC3) =NC=C2) C4=C (F) C (F) =C (NS (CC5=CC=CC=C5) (=O) =O) C (F) =C4
Molecular Formula
C27H24F4N6O3S
Molecular Weight
588.58
Storage Conditions
-20°C
Notes
For research use only.

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