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G-5758

CAT: 0804-HY-161672-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-161672-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
G-5758 is a selective and orally effective IRE1α inhibitor with an IC50 of 38 nM (detected by the XBP1s luciferase reporter cell assay) . G-5758 is still well tolerated in rats at oral doses up to 500 mg/kg. G-5758 can be used in the research of multiple myeloma[1].
CAS Number
2413455-99-7
UNSPSC
12352005
Target
IRE1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/g-5758.html
Concentration
10mM
Purity
98.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(F)C(NS(CC2=CC=CC=C2)(=O)=O)=C(F)C=C1OC3=C(C=CC=N3)C4=CC=NC(N[C@H]5C[C@H](F)CNC5)=N4
Molecular Formula
C27H24F4N6O3S
Molecular Weight
588.58
References & Citations
[1]Braun MG, et al. Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model. J Med Chem. 2024 Jun 13;67 (11) :8708-8729.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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