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AKP-11

CAT: 0013-GTR19232372-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19232372-01Size:10 mg
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Description
AKP-11 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist with an EC50 of 0.047 μM for [35S]GTPγS binding to CHO-K1 cell membranes expressing human S1P1. It reduces S1P1 surface expression and enhances Akt and ERK phosphorylation in CHO cells with S1P1-HA at a 100 nM concentration. At doses of 1.3 and 3 mg/kg, AKP-11 lowers IFN-γ and IL-17 protein levels in the spinal cord and mitigates disease severity in a rat experimental autoimmune encephalomyelitis (EAE) model. Additionally, it decreases peripheral total lymphocyte and specific T cell subsets (CD4+, CD8+, and CD26L+ T cells) counts in both EAE rats and healthy controls at a 1.3 mg/kg dosage.
CAS Number
1220973-37-4
Field of Research
Pharmacology & Drug Discovery
Smiles
ClC=1C=C (C=CC1OCCC) C2=NC (=NO2) C=3C=CC=4OC (=CC4C3) C (N) (CO) CO
Molecular Formula
C22H22ClN3O5
Molecular Weight
443.88
Storage Conditions
-20°C
Notes
For research use only.

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