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JNJ-1013

CAT: 0013-GTR19231259Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19231259Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JNJ-1013 is a potent and selective PROTAC degrader of IRAK1 (IC50=72 nM) . It demonstrates antiproliferative and proapoptotic activity in vitro by reducing IRAK1 levels and downstream signaling via NF-κB and STAT3 pathways, supporting its investigation in oncology research.
CAS Number
2597343-08-1
Product Name Alternative
JNJ1013
Field of Research
Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.59% (May vary between batches)
Solubility
DMSO:20 mg/mL (22.78 mM)
Smiles
C ([C@@H] (NC (COC1CCN (CC1) C2=CC (OC) =C (NC (=O) C=3N=C (C=CC3) C=4C=CNN4) C=C2) =O) C (C) (C) C) (=O) N5[C@H] (C (N[C@@H] (C) C6=CC=C (C=C6) C=7SC=NC7C) =O) C[C@@H] (O) C5
Molecular Formula
C46H55N9O7S
Molecular Weight
878.05
Storage Conditions
-20°C
Notes
For research use only.

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