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Usnoflast

CAT: 0013-GTR19230195-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19230195-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Usnoflast (ZYIL1) is an orally bioavailable, selective NLRP3 inflammasome inhibitor. Its application in research includes investigating neuroinflammatory pathways in models of neurological diseases, both in vitro and in vivo, due to its ability to suppress NLRP3-driven inflammation.
CAS Number
2455519-86-3
Product Name Alternative
NLR, NODlikeReceptor (NLR), NOD-like Receptor, NODlike Receptor (NLR), NODlikeReceptor, ZYIL1, ZYIL-1
Field of Research
Immunology & Inflammation, Signal Transduction
Purity
98.79% (May vary between batches)
Solubility
DMSO:50 mg/mL (123.9 mM)
Smiles
N (C (NS (/C=C/[C@]1 (C) N (C) CCC1) (=O) =O) =O) C2=C3C (=CC4=C2CCC4) CCC3
Molecular Formula
C21H29N3O3S
Molecular Weight
403.54
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Usnoflast

NLRP3 inflammasome inhibitor

CAS Number2455519-86-3
PubChem CID154648184
IUPAC Name1-[(E)-2-[(2R)-1,2-dimethylpyrrolidin-2-yl]ethenyl]sulfonyl-3-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)urea
Molecular FormulaC21H29N3O3S
Molecular Weight403.5
XLogP3.6
Topological Polar Surface Area86.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count28
Formal Charge0
Complexity712
SMILES
C[C@@]1(CCCN1C)/C=C/S(=O)(=O)NC(=O)NC2=C3CCCC3=CC4=C2CCC4
InChI
InChI=1S/C21H29N3O3S/c1-21(10-5-12-24(21)2)11-13-28(26,27)23-20(25)22-19-17-8-3-6-15(17)14-16-7-4-9-18(16)19/h11,13-14H,3-10,12H2,1-2H3,(H2,22,23,25)/b13-11+/t21-/m1/s1
InChIKey
HAMGPBKPACGWND-ZOXUKVPXSA-N
Chemical Structure
2D Structure
2D structure of Usnoflast
CAS: 2455519-86-3
CID: 154648184
Formula: C21H29N3O3S
MW: 403.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight403.5
XLogP33.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass403.19296297
Monoisotopic Mass403.19296297
Topological Polar Surface Area86.9 Ų
Heavy Atom Count28
Formal Charge0
Complexity712
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T79864-01Usnoflast
CS-O-57590Usnoflast-d3

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