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Usnoflast

CAT: 0804-HY-156647-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-156647-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Usnoflast is the selective, orally active inhibitor for NLRP3 that blocks the release of IL-1β, and exhibits anti-inflammatory activity[1][2].
CAS Number
2455519-86-3
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/usnoflast.html
Purity
98.29
Solubility
DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@]1(N(CCC1)C)/C=C/S(NC(NC2=C3C(CCC3)=CC4=C2CCC4)=O)(=O)=O
Molecular Formula
C21H29N3O3S
Molecular Weight
403.54
References & Citations
[1]Sharma, et al. Novel substituted sulfonylurea derivatives as NLRP3 modulators and their preparation. World Intellectual Property Organization, WO2020148619 A1. 2020-07-23.|[2]Chatterjee A, et al., A novel selective NLRP3 inhibitor shows disease-modifying potential in animal models of Parkinson's disease. Brain Res. 2024 Nov 1;1842:149129.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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