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TH-Z827

CAT: 0013-GTR19230710-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19230710-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TH-Z827 is a mutant-selective small molecule inhibitor targeting KRAS (G12D) with an IC50 of 2.4 μM, showing no activity against KRAS (WT) or KRAS (G12C) . It also disrupts the KRAS (G12D) -CRAF interaction (IC50 = 42 μM) . This compound is a valuable research tool for investigating mutant-specific KRAS signaling in cancer cell-based and biochemical assays.
CAS Number
2847881-81-4
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
O (C[C@H]1N (C) CCC1) C2=NC (=C3C (CN (CC3) C=4C5=C (C=CC4) C=CC=C5C) =N2) N6C7CCC6CNC7
Molecular Formula
C30H38N6O
Molecular Weight
498.66
Storage Conditions
-20°C
Notes
For research use only.

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