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4-N3Pfp-NHS ester

CAT: 0013-GTR19226073-02Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19226073-02Size:500 mg
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Description
The 4-N3Pfp-NHS ester is a non-cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) . This reagent enables stable covalent attachment of cytotoxic payloads to antibodies, facilitating the development of targeted cancer therapeutics for both in vitro and in vivo research applications.
CAS Number
126695-58-7
Field of Research
Pharmacology & Drug Discovery
Smiles
Fc1c (F) c (C (=O) ON2C (=O) CCC2=O) c (F) c (F) c1N=[N+]=[N-]
Molecular Formula
C11H4F4N4O4
Molecular Weight
332.17
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-Succinimidyl 4-Azido-2,3,5,6-tetrafluorobenzoate
CAS Number126695-58-7
PubChem CID2762579
IUPAC Name(2,5-dioxopyrrolidin-1-yl) 4-azido-2,3,5,6-tetrafluorobenzoate
Molecular FormulaC11H4F4N4O4
Molecular Weight332.17
XLogP2.2
Topological Polar Surface Area78
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Heavy Atom Count23
Formal Charge0
Complexity552
SMILES
C1CC(=O)N(C1=O)OC(=O)C2=C(C(=C(C(=C2F)F)N=[N+]=[N-])F)F
InChI
InChI=1S/C11H4F4N4O4/c12-6-5(7(13)9(15)10(8(6)14)17-18-16)11(22)23-19-3(20)1-2-4(19)21/h1-2H2
InChIKey
HCTLWQSYGIBOFM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-Succinimidyl 4-Azido-2,3,5,6-tetrafluorobenzoate
CAS: 126695-58-7
CID: 2762579
Formula: C11H4F4N4O4
MW: 332.17
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight332.17
XLogP32.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Exact Mass332.01686727
Monoisotopic Mass332.01686727
Topological Polar Surface Area78 Ų
Heavy Atom Count23
Formal Charge0
Complexity552
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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