Products for Research Use Only
RegisterLogin

BI-3663

CAT: 0013-GTR19225889-02Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19225889-02Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
BI-3663 is a potent and selective PROTAC degrader of PTK2/FAK, achieving degradation with an IC50 of 18 nM by recruiting cereblon E3 ligase. This molecule, derived from BI-4464 and pomalidomide, has demonstrated anti-cancer activity in cellular assays and is a valuable chemical probe for investigating FAK-dependent oncology and metastasis research.
CAS Number
2341740-84-7
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C (NCCOCCOCCOCCC (=O) NC1=CC=CC=2C (=O) N (C (=O) C12) C3C (=O) NC (=O) CC3) C4=CC=C (NC5=NC=C (C (=N5) OC6=CC=CC7=C6C (=O) CC7) C (F) (F) F) C (OC) =C4
Molecular Formula
C44H42F3N7O12
Molecular Weight
917.84
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-3-{2-[2-(2-{[3-methoxy-4-({4-[(3-oxo-2,3-dihydro-1H-inden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl}amino)phenyl]formamido}ethoxy)ethoxy]ethoxy}propanamide
CAS Number2341740-84-7
PubChem CID137628657
IUPAC NameN-[2-[2-[2-[3-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethyl]-3-methoxy-4-[[4-[(3-oxo-1,2-dihydroinden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide
Molecular FormulaC44H42F3N7O12
Molecular Weight917.8
XLogP2.9
Topological Polar Surface Area243
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count18
Rotatable Bond Count20
Heavy Atom Count66
Formal Charge0
Complexity1760
SMILES
COC1=C(C=CC(=C1)C(=O)NCCOCCOCCOCCC(=O)NC2=CC=CC3=C2C(=O)N(C3=O)C4CCC(=O)NC4=O)NC5=NC=C(C(=N5)OC6=CC=CC7=C6C(=O)CC7)C(F)(F)F
InChI
InChI=1S/C44H42F3N7O12/c1-62-33-22-25(8-10-28(33)51-43-49-23-27(44(45,46)47)40(53-43)66-32-7-2-4-24-9-12-31(55)36(24)32)38(58)48-15-17-64-19-21-65-20-18-63-16-14-35(57)50-29-6-3-5-26-37(29)42(61)54(41(26)60)30-11-13-34(56)52-39(30)59/h2-8,10,22-23,30H,9,11-21H2,1H3,(H,48,58)(H,50,57)(H,49,51,53)(H,52,56,59)
InChIKey
ADTXLFJKQHYGPM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-3-{2-[2-(2-{[3-methoxy-4-({4-[(3-oxo-2,3-dihydro-1H-inden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl}amino)phenyl]formamido}ethoxy)ethoxy]ethoxy}propanamide
CAS: 2341740-84-7
CID: 137628657
Formula: C44H42F3N7O12
MW: 917.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight917.8
XLogP32.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count18
Rotatable Bond Count20
Exact Mass917.28435429
Monoisotopic Mass917.28435429
Topological Polar Surface Area243 Ų
Heavy Atom Count66
Formal Charge0
Complexity1760
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR17970173Bi Antibody
GTR19156458-01BI-671800
GTR19178346-01BI-749327
GTR19233355-01BI-4732
GTR19339331-01DFHBI-BI
GTR19212103-01BI‐3231
GTR19211647-01BI-831266
GTR19208969-01BI-665915
GTR19208850-01BI-2865
GTR19206437-01BI 653048

Alternative Products

CatalogName
BA8925-5.1BI-3663
A19455-50BI-3663 50mg
A19455-25BI-3663 25mg
A19455-100BI-3663 100mg
A19455-1BI-3663 1mg
A19455-10BI-3663 10mg
A19455-5BI-3663 5mg
HY-R00771A-01Hsa-miR-3663-5p agomir
HY-R00770-01Hsa-miR-3663-3p mimic
HY-R00770A-01Hsa-miR-3663-3p agomir

Popular Products