BI-3663

CAT: 0013-GTR19225889-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19225889-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

BI-3663 is a potent and selective PROTAC degrader of PTK2/FAK, achieving degradation with an IC50 of 18 nM by recruiting cereblon E3 ligase. This molecule, derived from BI-4464 and pomalidomide, has demonstrated anti-cancer activity in cellular assays and is a valuable chemical probe for investigating FAK-dependent oncology and metastasis research.

CAS Number

2341740-84-7

Field of Research

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Smiles

O=C (NCCOCCOCCOCCC (=O) NC1=CC=CC=2C (=O) N (C (=O) C12) C3C (=O) NC (=O) CC3) C4=CC=C (NC5=NC=C (C (=N5) OC6=CC=CC7=C6C (=O) CC7) C (F) (F) F) C (OC) =C4

Molecular Formula

C44H42F3N7O12

Molecular Weight

917.84

Storage Conditions

-20°C

Notes

For research use only.

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BI-3663

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