Products for Research Use Only
RegisterLogin

PROTAC-O4I2

CAT: 0013-GTR19221439-04Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19221439-04Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PROTAC-O4I2 is a heterobifunctional degrader that targets the splicing factor SF3B1, inducing its degradation with an IC50 of 0.244 μM in K562 cells and triggering apoptosis. This molecule serves as a valuable chemical probe for studying RNA splicing mechanisms and cancer cell survival in leukemia research models.
CAS Number
2785323-62-6
Product Name Alternative
Apoptosis, PROTAC
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
96.31% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (8.21 mM) ; DMSO:200 mg/mL (328.35 mM)
Smiles
O=C1C=2C (C (=O) N1C3C (=O) NC (=O) CC3) =CC=CC2NCCCCCCNC (=O) C=4N=C (NC5=CC=C (Cl) C=C5) SC4
Molecular Formula
C29H29ClN6O5S
Molecular Weight
609.1
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Protac-O4I2

PROTAC-O4I2 is an organic molecular entity.

CAS Number2785323-62-6
PubChem CID162641046
IUPAC Name2-(4-chloroanilino)-N-[6-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]hexyl]-1,3-thiazole-4-carboxamide
Molecular FormulaC29H29ClN6O5S
Molecular Weight609.1
XLogP4.9
Topological Polar Surface Area178
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count12
Heavy Atom Count42
Formal Charge0
Complexity1030
SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCCCCCNC(=O)C4=CSC(=N4)NC5=CC=C(C=C5)Cl
InChI
InChI=1S/C29H29ClN6O5S/c30-17-8-10-18(11-9-17)33-29-34-21(16-42-29)25(38)32-15-4-2-1-3-14-31-20-7-5-6-19-24(20)28(41)36(27(19)40)22-12-13-23(37)35-26(22)39/h5-11,16,22,31H,1-4,12-15H2,(H,32,38)(H,33,34)(H,35,37,39)
InChIKey
UWYLVQJEOCYCEW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Protac-O4I2
CAS: 2785323-62-6
CID: 162641046
Formula: C29H29ClN6O5S
MW: 609.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight609.1
XLogP34.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count12
Exact Mass608.1608669
Monoisotopic Mass608.1608669
Topological Polar Surface Area178 Ų
Heavy Atom Count42
Formal Charge0
Complexity1030
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19174876-01O4I2
GTR19160460-01O4I2
GTR19218046-01DA-PROTAC
GTR19218051-01BT-PROTAC
GTR19277107-01PROTAC A515
GTR19162789-01CDK9-PROTAC
GTR19222884-01PROTAC-I
GTR19249544-01PROTAC CG167
GTR19272718-01Usp39 PROTAC-V1
GTR19258526-01FKBP12 PROTAC FM4

Alternative Products

CatalogName
BA2779-5.1PROTAC-O4I2
522505O4I2
A16091-100O4I2 100mg

Popular Products