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O4I2

CAT: 0013-GTR19160460-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160460-01Size:200 mg
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Description
O4I2 is a potent inducers of Oct3/4. O4I2 showed high activity in enforcing Oct3/4 expression. O4I2 is a new class of small molecules suitable for iPSC generation. The octamer-binding transcription factor 4 (Oct3/4) is a master gene in the transcriptional regulatory network of pluripotent cells. Repression of Oct3/4 in embryonic stem cells (ESCs) is associated with cell differentiation and loss of pluripotency, whereas forced overexpression in cooperation with other transcriptional factors, such as Nanog, Sox2, and Lin28, can reprogram somatic cells back into pluripotent cells, termed induced pluripotent stem cells (iPSCs) .
CAS Number
165682-93-9
Product Name Alternative
O4I2 | O-4I2 | O4I-2
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 42 mg/mL; 148.54 mM
Smiles
CCOC (=O) c1csc (n1) Nc1ccc (cc1) Cl
Molecular Formula
C12H11ClN2O2S
Molecular Weight
282.75
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Ethyl 2- ((4-chlorophenyl) amino) thiazole-4-carboxylate

Chemical Information

Ethyl 2-((4-chlorophenyl)amino)thiazole-4-carboxylate

induces expression of octamer-binding transcription factor 4; structure in first source

CAS Number165682-93-9
PubChem CID53428670
IUPAC Nameethyl 2-(4-chloroanilino)-1,3-thiazole-4-carboxylate
Molecular FormulaC12H11ClN2O2S
Molecular Weight282.75
XLogP4
Topological Polar Surface Area79.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count18
Formal Charge0
Complexity285
SMILES
CCOC(=O)C1=CSC(=N1)NC2=CC=C(C=C2)Cl
InChI
InChI=1S/C12H11ClN2O2S/c1-2-17-11(16)10-7-18-12(15-10)14-9-5-3-8(13)4-6-9/h3-7H,2H2,1H3,(H,14,15)
InChIKey
ULUBAPWNHROTEU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ethyl 2-((4-chlorophenyl)amino)thiazole-4-carboxylate
CAS: 165682-93-9
CID: 53428670
Formula: C12H11ClN2O2S
MW: 282.75
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight282.75
XLogP34
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass282.0229765
Monoisotopic Mass282.0229765
Topological Polar Surface Area79.5 Ų
Heavy Atom Count18
Formal Charge0
Complexity285
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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