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NU223612

CAT: 0013-GTR19220739-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19220739-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NU223612 is a brain-penetrant PROTAC degrader of indoleamine 2,3-dioxygenase 1 (IDO1) that recruits the CRBN E3 ligase. With affinities of 640 nM for IDO1 and 290 nM for CRBN, it induces proteasomal degradation. This molecule is a valuable tool for investigating IDO1's role in immunology and neuroscience in both cellular and animal models.
CAS Number
2759420-43-2
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Smiles
O=C1C=2C (C (=O) N1C3C (=O) NC (=O) CC3) =CC=CC2NCCOCCOCCC (=O) N4CCC (OC5=CC=C (NC ([C@H] (C) [C@@]6 (CC[C@@H] (CC6) C=7C8=C (N=CC7) C=CC (F) =C8) [H]) =O) C=C5) CC4
Molecular Formula
C49H55FN6O9
Molecular Weight
890.99
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
MBS5816915NU223612

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