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MK-0533

CAT: 0013-GTR19219638-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19219638-03Size:10 mg
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Description
MK-0533 is a selective PPARγ partial agonist developed for research into vascular endothelial dysfunction (VED) and associated cardiovascular disorders. It serves as a pharmacological tool for investigating PPARγ-mediated pathways in both in vitro cellular models and in vivo studies of endothelial function and vascular health.
CAS Number
668455-28-5
Product Name Alternative
MK0533, MK-0533, MK 0533, PPARγ
Field of Research
Metabolism Research, Molecular Biology
Purity
99.03% (May vary between batches)
Solubility
DMSO:55 mg/mL (104.27 mM)
Smiles
CC=1N (C=2C (C1C (=O) C3=CC=C (OC) C=C3) =CC=C (OC (F) (F) F) C2) C4=CC (O[C@@H] (C (O) =O) CC) =CC=C4
Molecular Formula
C28H24F3NO6
Molecular Weight
527.49
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Mk-0533

MK-0533 is under investigation in clinical trial NCT00543959 (Efficacy and Tolerability of MK0533 in Patients With Type 2 Diabetes (0533-005)).

CAS Number668455-28-5
PubChem CID11678534
IUPAC Name(2R)-2-[3-[3-(4-methoxybenzoyl)-2-methyl-6-(trifluoromethoxy)indol-1-yl]phenoxy]butanoic acid
Molecular FormulaC28H24F3NO6
Molecular Weight527.5
XLogP7
Topological Polar Surface Area87
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Heavy Atom Count38
Formal Charge0
Complexity817
SMILES
CC[C@H](C(=O)O)OC1=CC=CC(=C1)N2C(=C(C3=C2C=C(C=C3)OC(F)(F)F)C(=O)C4=CC=C(C=C4)OC)C
InChI
InChI=1S/C28H24F3NO6/c1-4-24(27(34)35)37-20-7-5-6-18(14-20)32-16(2)25(26(33)17-8-10-19(36-3)11-9-17)22-13-12-21(15-23(22)32)38-28(29,30)31/h5-15,24H,4H2,1-3H3,(H,34,35)/t24-/m1/s1
InChIKey
STWITCBWQHTJFJ-XMMPIXPASA-N
Chemical Structure
2D Structure
2D structure of Mk-0533
CAS: 668455-28-5
CID: 11678534
Formula: C28H24F3NO6
MW: 527.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight527.5
XLogP37
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Exact Mass527.15557197
Monoisotopic Mass527.15557197
Topological Polar Surface Area87 Ų
Heavy Atom Count38
Formal Charge0
Complexity817
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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