MK-0752

MK-0752

• CAS Number: 471905-41-6
• UNSPSC Description: MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Aβ in vivo[1][2].
• Target Antigen: γ-secretase
• Type: Reference compound
• Related Pathways: Neuronal Signaling;Stem Cell/Wnt
• Applications: Cancer-programmed cell death
• Field of Research: Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/MK-0752.html
• Purity: 99.35
• Solubility: DMSO : ≥ 100 mg/mL|Ethanol : 10 mg/mL (ultrasonic)
• Smiles: O=S([C@@]1(C2=C(C=CC(F)=C2)F)CC[C@@H](CCC(O)=O)CC1)(C3=CC=C(Cl)C=C3)=O
• Molecular Weight: 442.90
• References & Citations: [1]Cook JJ, et al. Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound. J Neurosci. 2010;30(19):6743-6750.|[2]Krop I, et al. Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors. J Clin Oncol. 2012;30(19):2307-2313.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Phase 4