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Pimicotinib

CAT: 0013-GTR19218751-03Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19218751-03Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pimicotinib (ABSK021) is a highly selective and potent CSF1R inhibitor used in preclinical research. It demonstrates antitumor activity in models of advanced solid tumors, including tenosynovial giant cell tumor, by targeting tumor-associated macrophages in both in vitro and in vivo studies.
CAS Number
2253123-16-7
Product Name Alternative
ABSK021, ABSK-021, CSF1R, cFms
Field of Research
Cardiovascular Research, Signal Transduction
Purity
99.80% (May vary between batches)
Solubility
DMSO:150 mg/mL (356.75 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.76 mM)
Smiles
O=C (NC=1N=C (C (OC2=CC=NC (=C2) C=3C=NN (C3) C) =CC1) C) N4C (=O) C (C) (C) CC4
Molecular Formula
C22H24N6O3
Molecular Weight
420.46
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Pimicotinib

Pimicotinib is under investigation in clinical trial NCT05804045 (Study of Pimicotinib (ABSK021) for Tenosynovial Giant Cell Tumor (MANEUVER)). It was initially developed by Abbisko Therapeutics Co in collaboration with Merck KGaA. Pimicotinib was granted Fast Track Designation in December 2023 by the FDA.

CAS Number2253123-16-7
PubChem CID139549388
IUPAC Name3,3-dimethyl-N-[6-methyl-5-[[2-(1-methylpyrazol-4-yl)-4-pyridinyl]oxy]-2-pyridinyl]-2-oxopyrrolidine-1-carboxamide
Molecular FormulaC22H24N6O3
Molecular Weight420.5
XLogP2
Topological Polar Surface Area102
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count31
Formal Charge0
Complexity674
SMILES
CC1=C(C=CC(=N1)NC(=O)N2CCC(C2=O)(C)C)OC3=CC(=NC=C3)C4=CN(N=C4)C
InChI
InChI=1S/C22H24N6O3/c1-14-18(31-16-7-9-23-17(11-16)15-12-24-27(4)13-15)5-6-19(25-14)26-21(30)28-10-8-22(2,3)20(28)29/h5-7,9,11-13H,8,10H2,1-4H3,(H,25,26,30)
InChIKey
NXFPMDWYDKHFMM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pimicotinib
CAS: 2253123-16-7
CID: 139549388
Formula: C22H24N6O3
MW: 420.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight420.5
XLogP32
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass420.19098865
Monoisotopic Mass420.19098865
Topological Polar Surface Area102 Ų
Heavy Atom Count31
Formal Charge0
Complexity674
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
M37228-01Pimicotinib
HY-153920APimicotinib (hydrochloride)
T204920-01Pimicotinib hydrochloride

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