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84-B10

CAT: 0804-HY-44307-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-44307-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI).
CAS Number
698346-43-9
UNSPSC
12352005
Target
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/84-b10.html
Concentration
10mM
Purity
99.61
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)CC(CC(NC1=CC(C(F)(F)F)=CC=C1OC2=CC=C(OC)C=C2)=O)C3=CC=CC=C3
Molecular Formula
C25H22F3NO5
Molecular Weight
473.44
References & Citations
[1]Fan J, et, al. A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis. Free Radic Biol Med. 2023 Jan;194:84-98.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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