Products for Research Use Only

Octreotide acetate

CAT: 0013-GTR19217337-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19217337-01Size:500 mg
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Description
An octapeptide that mimics natural somatostatin pharmacologically, that is 200 times more potent than somatostatin; has also been shown to produce analgesic effects, most probably acting as a partial agonist at the mu opioid receptor. (In Vivo) :Octreotide-treated groups show a significant reduction in the tumor volume when compared with saline group. Octreotide-PPSG (1.4 mg/kg, i.p.) shows greater antitumor effect than Octreotide-soln (100 μg/kg, i.p.) . Octreotide-treatments results in significant inhibitory effect on the expression levels of SSTR2 and SSTR5 in primary HCC-bearing rats compared with the saline group. Octreotide-PPSG appears to inhibit the expression of SSTR2 and SSTR5 to a greater extent than that of Octreotide-soln treated group. A test dose of octreotide acetate significantly decreases the serum gastrin level to approximately one third of the baseline in 2 hr and the effect lasted approximately for 6 hr. On day 21, treatment with sustained-release formulation of octreotide acetatea (5 mg intramuscular, q 4 wk) is initiated.
CAS Number
79517-01-4
Product Name Alternative
SMS-201995
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 29 mg/mL
Smiles
CC (C1C (=O) NC (CSSCC (C (=O) NC (C (=O) NC (C (=O) NC (C (=O) N1) CCCCN) CC2=CNC3=CC=CC=C32) CC4=CC=CC=C4) NC (=O) C (CC5=CC=CC=C5) N) C (=O) NC (CO) C (C) O) O
Molecular Formula
C51H70N10O12S2
Molecular Weight
1079.291
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[ (1R,2R) -2-hydroxy-1- (hydroxymethyl) propyl]-, cyclic (2→7) -disulfide, acetate (1:?)