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Lanoconazole

CAT: 0013-GTR19217036-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19217036-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis. Lanoconazole (treatment for ear; 0.3%-3%; 6 days) dose‐dependently suppresses TPA-induced irritant dermatitis, suppresses the production of neutrophil chemotactic factors such as keratinocyte‐derived chemokine and macrophage inflammatory protein‐2, and inhibited neutrophil infiltration to the inflammation site. Lanoconazole (oral administration; 3, 10 or 30 mg/kg; once a day; 3 weeks) significantly inhibits C. neoformans compared with the saline control in normal mice. In addtion, it significantly reduces the growth of C. neoformans in the lungs and brains of MAIDS mice.
CAS Number
101530-10-3
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO : 100 mg/mL (312.67 mM; Need ultrasonic)
Smiles
N#C/C (N1C=CN=C1) =C2SC (C (C=CC=C3) =C3Cl) CS\2.[ (E) ]
Molecular Formula
C14H10ClN3S2
Molecular Weight
319.83
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

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MBS5803572(Z)-Lanoconazole
HY-14282R-01Lanoconazole (Standard)
TRC-L174502-25MGLanoconazole-d3
L1273Lanoconazole ((E) - (+/-) -μ-[4- (2-Chlorophenyl) -1,3-dithiolan-2-ylidene]-1H-imidazole-1-acetonitrile, Latoconazole, TJN-318, NND-318, Astat)
MBS6107093-01Lanoconazole ((E)-(+/-)-u-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene]-1H-imidazole-1-acetonitrile, Latoconazole, TJN-318, NND-318, Astat)
L1273-01Lanoconazole-d3 ((E) - (+/-) -μ-[4- (2-Chlorophenyl) -1,3-dithiolan-2-ylidene]-1H-imidazole-d3-1-acetonitrile, Latoconazole-d3, TJN-318-d3, NND-318-d3, Astat-d3)
MBS6067842-01Lanoconazole-d3 ((E)-(+/-)-u-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene]-1H-imidazole-d3-1-acetonitrile, Latoconazole-d3, TJN-318-d3, NND-318-d3, Astat-d3)

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