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Azosemide

CAT: 0013-GTR19216970-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216970-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Azosemide is a potent NKCC1 inhibitor (IC50s: 0.246 μM and 0.197 μM for hNKCC1A and NKCC1B) . (In Vitro) :Azosemide inhibits the sodium-potassium-chloride-cotransporter human variants hNKCC1B and hNKCC1A . (In Vivo) :Azosemide shows a shorter terminal half-life (50.9% decrease) and MRT (64.1% decrease), smaller AUC (81.9% decrease), faster CL (454% increase), CLNR (307% increase) and CLR (853% increase) for NARs .
CAS Number
27589-33-9
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 250 mg/mL (674.15 mM)
Smiles
NS (=O) (=O) c1cc (-c2nnn[nH]2) c (NCc2cccs2) cc1Cl
Molecular Formula
C12H11ClN6O2S2
Molecular Weight
370.83
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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