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NMS-P715

CAT: 0013-GTR19216925-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216925-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor (IC50 of 182 nM) . (In Vitro) :NMS-P715 (1 μM) inhibits the proliferation of HCT116 cells. And it causes mitotic acceleration in U2OS cells overexpressing YFP-α-tubulin, induces aneuploidy. NMS-P715 (0.5, 1 μM) affects mitotic checkpoint complex (MCC) stability and cdc20 ubiquitylation. (In Vivo) :NMS-P715 (90 mg/kg, p.o.) is well tolerated and causes no signs of body weight loss or other overt toxicities in an A2780 ovary carcinoma xenograft model.
CAS Number
1202055-32-0
Field of Research
Neuroscience
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 2 mg/mL (2.96 mM)
Smiles
CCc1cccc (CC) c1NC (=O) c1nn (C) c-2c1CCc1cnc (Nc3ccc (cc3OC (F) (F) F) C (=O) NC3CCN (C) CC3) nc-21
Molecular Formula
C35H39F3N8O3
Molecular Weight
676.745
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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