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TM-25659

CAT: 0013-GTR19216906-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216906-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TM-25659 is a modulator of transcriptional co-activator with PDZ-binding motif (TAZ), with anti-osteoporotic and anti-obesity activities. (In Vitro) :Treatment with TM-25659 (2, 10, 20, 100 μM) dose-dependently enhances nuclear TAZ localization and attenuates PPARγ-mediated adipocyte differentiation by facilitating PPARγ suppression activity of TAZ. Osteogenic gene expression is enhanced by TM-25659 (2, 10, 50 μM) and thereby osteoblast differentiation is increased. (In Vivo) :In vivo, TM-25659 (50 mg/kg, i.p., every other day for 2 weeks) suppresses bone loss and decreases weight gain in an obesity model. The plasma concentration of TM-25659 declines with an approximate t1/2 of 7 or 10 h following i.v or p.o. administration respectively. The systemic clearance (CL) is 0.21 L/ (hxkg) and the volume of distribution at steady-state (1.91 L/ (hxkg) ) is larger than the volume of total body fluids.
CAS Number
260553-97-7
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : ≥ 135 mg/mL (269.68 mM)
Smiles
CCCCc1nc2cc (-c3cccnc3) c (C) nc2n1Cc1ccc (cc1) -c1ccccc1-c1nn[nH]n1
Molecular Formula
C30H28N8
Molecular Weight
500.6
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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