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UNC6852

CAT: 0013-GTR19216884-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216884-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC. (In Vitro) :UNC6852 (10 μM; 1-72 hours) results in a decrease in the levels of both EED and EZH2. UNC6852 facilitates PRC2 degradation via VHL recruitment and reduces H3K27me3 levels and DLBCL cell proliferation. UNC6852 displays no cellular toxicity at concentrations up to 30 μM for HeLa Cells.
CAS Number
2688842-08-0
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (120.05 mM)
Smiles
CCc (n (Cc1ccccc1) c1ccc2) c (C (C (N) =O) =O) c1c2OCC (OC) =O
Molecular Formula
C22H22N2O5
Molecular Weight
394.42
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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