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9-Phenanthrol

CAT: 0013-GTR19216957-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216957-01Size:500 mg
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Description
9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel. (In Vitro) :In addition, 9-phenanthrol, lacking the chemical groups necessary for CFTR activation, also reversibly inhibited TRPM4 with a similar IC (50) . Channel inhibition was voltage independent. The IC (50) determined in the whole-cell and inside-out experiments were similar, suggesting a direct effect of the molecule. However, 9-phenanthrol was ineffective on TRPM5, the most closely related channel within the TRP protein family. We identify 9-phenanthrol as a TRPM4 inhibitor, without effects on TRPM5. It could be valuable in investigating the physiological functions of TRPM4, as distinct from those of TRPM5.
CAS Number
484-17-3
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (514.85 mM)
Smiles
Oc1cc2ccccc2c2ccccc12
Molecular Formula
C14H10O
Molecular Weight
194.233
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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