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Bemnifosbuvir

CAT: 0013-GTR19216433-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216433-01Size:200 mg
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Description
Bemnifosbuvir is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV. (In Vitro) :AT-511 is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV.In the absence of cells, AT-511 was stable when incubated in culture medium at 37°C for up to 24 h. AT-9010 was the predominant intracellular metabolite measured in all hepatocyte species and Huh-7 cell incubations with 10 μM AT-511 and, except in mouse hepatocytes, far exceeded intracellular AT-511 concentrations, demonstrating that the active TP was efficiently formed from its phosphoramidate protide in liver cells. In hepatocyte incubations, the relative levels of AT-9010 formed, and its accumulation over 24 h expressed as area under the curve or AUC0-24h; from most to least abundant, were rat>human >mouse >dog/monkey. (In Vivo) :Treatment with moxifloxacin every 8 hr was accompanied by longer survival than in any other group.Tissue cultures 30 hr after bacterial challenge showed considerably less bacterial growth in the spleens and lungs of moxifloxacin-treated animals than in the other groups, but not in their livers.
CAS Number
1998705-64-8
Product Name Alternative
AT-511
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 200 mg/mL (343.92 mM)
Smiles
CC (OC ([C@@H] (N[P@] (OC[C@@H]1[C@H] ([C@] (C) ([C@] (N2C=NC3=C (N=C (N=C32) N) NC) (O1) [H]) F) O) (OC4=CC=CC=C4) =O) C) =O) C
Molecular Formula
C24H33FN7O7P
Molecular Weight
581.53
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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