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CYM50358

CAT: 0013-GTR19216387-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216387-01Size:200 mg
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Description
N- (4- (aminomethyl) -2,6-dimethylphenyl) -5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4) . CYM50358 inhibits S1P4 with an IC50 of 25 nM. (In Vitro) :N- (4- (aminomethyl) -2,6-dimethylphenyl) -5 shows less potent inhibition of S1PR1 (IC50=6.4μM) .N- (4- (aminomethyl) -2,6-dimethylphenyl) -5 (10μM) has no effect on the collagen-induced HSP27 phosphorylation, markedly reverses the suppressive effect of S1P on the collagen-induced phospphorylation of HSP27.
CAS Number
1314212-39-9
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 125 mg/mL (321.11 mM)
Smiles
Cc1cc (CN) cc (C) c1NC (=O) c1ccc (o1) -c1cc (Cl) ccc1Cl
Molecular Formula
C20H18Cl2N2O2
Molecular Weight
389.28
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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